Building Blocks

Acetals Acid Chlorides & Fluorides Adamantanes Alcohols Aldehydes Alkanes & Alkenes Alkyl halides Alkynes Amides Amidines Amines Anhydrides Anilines Anthracenes Azaindoles/Pyrrolopyridines Azepanes Azetidines Azides Aziridines Benzaldehydes Benzimidazoles Benzodioxanes Benzodioxoles Benzofuranes Benzothiazoles Benzothiophenes Benzotriazoles Benzoxazoles beta-Lactames Binaphthyls Biphenyls Carbamates Carbazoles Carboxylic Acids Chromanes & Chromanones Coumarines Crown Ethers Cyclobutanes Cyclopropanes Diazanonanes 1,3-Dioxolanes Esters Ethers Fluorinated Building Blocks Furanes Fused Ring Systems Hydrazines & Hydrazides Hydroxylamines Imidazo[1,2-a]pyridines Imidazoles Indazoles Indoles Indolines Isocyanates & Isothiocyanates Isoquinolines Isothiazoles Isoxazoles Ketones Lactames Lactones Morpholines Naphthalenes Naphthyridines Nitriles Nitro Compounds Oxadiazoles Oxazoles Oxazolidines Oxazolines Oxetanes Oximes Oxiranes Perfluoroalkanes Phenanthrolines Phenazines Phenols & Naphthols Phthalazines Phthalimides Piperazines Piperidines Porphins & Porphyrins Prolines Pyranes & Pyrones Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines/Maleimides/NHS-Esters Quinazolines Quinolines Quinoxalines Quinuclidines Semicarbazides SF5 Compounds Spiro Compounds Styrenes Sulfanes & Sulfides Sulfonamides Sulfones Sulfonic Acids & Sulfonates Sulfonyl Chlorides & Fluorides Tetrahydrofuranes Tetrahydropyranes Tetrazoles 1,2,3-Thiadiazoles 1,2,4-Thiadiazoles 1,2,5-Thiadiazoles 1,3,4-Thiadiazoles Thiazoles Thiazolidines Thiazolines Thiols Thiophenes Thiophenols Tosylates 1,2,4-Triazines 1,3,5-Triazines 1,2,4-Triazoles Trifluoromethyl Compounds Urea Derivatives

Building blocks from abcr – information, facts, application areas

Building BlocksBuilding Blocks

The pharmaceutical industry has especially used building blocks intensively since the 1990s as these are used for researching pharma-active agents. Building blocks often function like “libraries”, i.e. as a carefully chosen selection of a few hundred to thousand building blocks for screening new active agents.

Building blocks are synthesis building blocks, which are used to produce organic molecules. Building blocks most often have one or multiple functional groups. Moreover, they are linked to other synthesis building blocks: Heterocyclic core structures such as pyridine, pyrrolidine or thiophene can be substituted with functional groups such as alcohols, aldehydes, carbonic acid, amines, amides, sulphonic acids, boronic acids, anhydrides, esters, nitriles, nitro compounds, diazo compounds, cyanates, isocyanates, alkenes, alkines or fluorine-containing groups.

Methods from combinatorial chemistry allow for the parallel synthesis of a multitude of similarly structured molecules. Suitable reaction conditions can cause building blocks to react in a targeted manner with high yields. The palladium-catalysed cross-coupling of Heck, Negishi and Suzuki is to be mentioned here as an example. In 2010, all three research groups received the Nobel Prize in Chemistry.

The introduction of fluorine substitutes in active agents has proven exceptionally advantageous. The pharmacokinetic properties can thereby be improved.

Buildings blocks in the abcr catalogue – find your desired molecule

Our unique building blocks for medical chemistry include

  • linked amino acids,
  • special chiral building blocks and
  • more than 80,000 fluorine-substituted products.

In addition to medical chemistry, agricultural chemistry with focus on plant protection represents another important usage area for building blocks from abcr.

The abcr catalogue offers a choice of more than 200,000 building blocks. We have consolidated these for you into lucid categories.